Ergothioneine is a naturally occurring amino acid, and this compound is made in relatively few organisms, notably actinobacteria, cyanobacteria, and certain fungi.
The importance of ergothioneine in various diseases is expected to drive the market's growth
Ergothioneine accumulates at high levels in the body from diet and may play important physiological roles in human health and development and possibly in the prevention and treatment of disease. Blood levels of ergothioneine decline with age and onset of various diseases.
For instance, evidence shows that ET may affect cardiovascular health from a longitudinal study associating changes in blood metabolites with cardiometabolic diseases in 3236 subjects over 20 years. Out of 112 metabolites, higher blood ET had the most significant association with lower risk of cardiometabolic disease and mortality, independent of age, gender, fasting glucose, cholesterol and triglyceride levels, alcohol intake, and smoking status.
Moreover, dysfunction of the vascular endothelium is necessary to a wide range of cardiovascular disorders, including hypertension, atherosclerosis, chronic heart failure, coronary artery disease, and diabetes.
A possible major underlying mechanism for the benefits of ET in the cardiovascular system is the protection of the vascular endothelium, as previously mentioned for brain endothelium. Other studies revealed that ET protects endothelium from oxidative damage and cell death due to paraquat, hydrogen peroxide, high glucose, or oxidized-LDL exposure.
Factors affecting ergothioneine transport are expected to hamper the market growth.
ET can be found in most tissues with differential accumulation rates owing to different expressions of the transporter. High expression of the transporter, and hence high levels of ET, is observed in certain cells (e.g., blood cells, bone marrow, ocular tissues, brain, etc.) that are likely predisposed to oxidative stress.
North America region holds the largest market share in the global ergothioneine (EGT) market.
North America accounted for the largest revenue share in 2020, owing to the high prevalence of neurological disorders and rising cases of various diseases.
For instance, according to the Pan American Health Organization, Neurological disorders (NDs) are heterogeneous diseases that affect the body’s autonomic, peripheral and central nervous system. In 2019, region-wide Neurological conditions accounted for 533,172 deaths, 213,129 (40%) in men, and 320,043 (60%) in women and 32.9 deaths per 100,000 population (age-standardized), 33.1 deaths per 100,000 population in men and 32.2 deaths per 100,000 population in women.
Moreover, Age-standardized death rates vary across countries from a high in the United States of America (47.4 deaths per 100,000 population) to a low in Venezuela (6.6 deaths per 100,000 population).
The ability of ET to swell in the brain (although more work needs to be done to establish the distribution and cellular location of ET in the human brain, peripheral nervous system, and cerebrospinal fluid) and its neuroprotective capabilities in a range of models both in vitro and in vivo, have been very useful.
Evidence suggests that ET may protect the brain against oxidative damage and neuroinflammation, target underlying pathologies in neurodegeneration such as mitochondrial dysfunction and toxic amyloid accumulation, and even promote neurogenesis.
Competitive Landscape
The ergothioneine (EGT) market is competitive with the presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Mironova Labs, Tetrahedron, Blue California, Aktin Chemicals, Inc., Sobeo Biotech, Bloomage Bioactive, Sinonocy and Taizhou Tianhong Biochemistry Technology Co., Ltd.
The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the ergothioneine (EGT) market globally.
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