Tissue dissociation is a cell separation process that separates the human and animal tissues. It is performed with the help of isolation enzymes to maximize the outcome of functionally viable, dissociated cells.
Increasing focus on developing monoclonal antibodies and customization of the drug manufacturing process is driving the market growth.
N-linked glycosylation is a primary source of heterogeneity associated with recombinant monoclonal antibodies. It plays a key role in a myriad of drug properties associated with biological function.
In addition, the glycosylation profile of recombinant monoclonal antibodies is determined by the order of cell culture inputs that are carefully controlled to engineer the desired glycan distribution. The method is shown to be linear, accurate, specific, and precise for an IgG1 and IgG4 mAb supporting relative quantitation of mannose-5 in the range 0.811.0% and 1.06.2%, respectively.
The method can also be applied at several stages of the production process, from cell culture harvest to drug substance/drug product, and is responsive to routine GMP batch testing in a quality control laboratory. Testing upstream during cell culture rather than for product release allows for a more advanced product quality assessment as the glycosylation profile remains unchanged during downstream purification.
North America region holds the largest market share in the global tissue dissociation market.
North America accounted for the largest revenue share in 2020 and is expected to dominate over the forecast period, owing to a high focus on biotechnology-related research; the best research institutes, increasing demand for biopharmaceutical products in the region are expected to boost the market in the forecast period.
For instance, according to the frontiers, the biopharmaceutical industry is rapidly developing in the pharmaceutical industry, with enormous opportunities and implications for healthcare.
Moreover, opportunities in biopharmaceuticals have been increasing over the past decade due to the great effectiveness and the safety of these drugs. In addition, biopharmaceuticals offer several benefits, such as highly effective and potent action, fewer side effects, and the potential to cure diseases rather than merely treat the symptoms, significantly increasing the demand for biopharmaceutical products.
Competitive Landscape
The tissue dissociation market is vast with presence of local as well as global companies. Some of the key players which are contributing to the growth of the market include Miltenyi Biotec, Worthington Biochemical, Sigma-Aldrich, F. Hoffmann-La Roche, Becton Dickinson Biosciences, Thermo Fisher Scientific, StemCell Technologies, Inc., VitaCyte and Merck KGaA.
The major players are adopting several growth strategies such as product launches, acquisitions, and collaborations, which are contributing to the growth of the tissue dissociation market globally.
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