(PharmaNewsWire.Com, July 05, 2017 ) Use of acyl-CoA desaturase for maintaining structure and function of membranes within the cells of the organism acts as the reason for its wide use. To detail the pipeline overview, Market Research Hub (MRH) has reported a new report focusing on acyl-CoA desaturase in the research study titled as “Acyl-CoA Desaturase (Fatty Acid Desaturase or Delta 9 Desaturase or Stearoyl-CoA Desaturase or SCD or EC 1.14.19.1) - Pipeline Review, H1 2017” to its vast report database.
Acyl-CoA Desaturase (Fatty Acid Desaturase or Delta 9 Desaturase or Stearoyl-CoA Desaturase or SCD or EC 1.14.19.1) - Stearoyl-CoA desaturase 1 is a protein encoded by the SCD gene. It is an important enzyme in fatty acid metabolism and is involved in the regulation of inflammation and stress in distinct cell types, including cells, adipocytes, macrophages, endothelial cells, and myocytes. The complete loss of this fatty acid desaturase has been implicated in liver dysfunction and several inflammatory diseases such as dermatitis, atherosclerosis, and intestinal colitis. The report goes on to cover products from therapy areas like Gastrointestinal, Oncology and Infectious Disease which include indications Non-Alcoholic Steatohepatitis (NASH), Colorectal Cancer, Metabolic Disorders, HIV-Associated Lipodystrophy Syndrome, Liver Fibrosis, Metastatic Renal Cell Carcinoma, Non Alcoholic Fatty Liver Disease (NAFLD) and Obesity.
The research outlays comprehensive information on the Acyl-CoA Desaturase (Fatty Acid Desaturase or Delta 9 Desaturase or Stearoyl-CoA Desaturase or SCD or EC 1.14.19.1) targeted therapeutics development, completed with analysis by stage of development, indication, mechanism of action (MoA), route of administration (RoA), molecule type and development by companies. Furthermore, it reviews the key players involved in Acyl-CoA Desaturase targeted therapeutics development with respective active and dormant or discontinued projects. The main companies featured in the therapeutic development are Daiichi Sankyo Company Ltd, Galmed Pharmaceuticals Ltd, Johnson & Johnson, Novartis AG and Takeda Pharmaceutical Company Ltd.
Moreover, the drugs are also profiled along with the product description, mechanism of action, R&D progress with main drugs including Aramchol, Small Molecule to Inhibit SCD-1 for Nonalcoholic Steatohepatitis, Small Molecule to Inhibit SCD1 for Metabolic Disorders, Small Molecule to Inhibit Stearoyl-CoA Desaturase-1 for Obesity, Small Molecules to Inhibit SCD1 for Metastatic Renal Cell Carcinoma, and T-3764518. Lastly, the report has various news and press release links that are related to the pipeline review of the acyl-CoA desaturase and finally concludes with the detailed primary research, secondary research, and expert panel validation analysis which give a trustful overview and help in easy decision making by the experts.
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